Spike Neutralizing Antibody (Clone LxC1-G10) (SARS-CoV-2)

BPS Bioscience

Spike Neutralizing Antibody (Clone LxC1-G10) (SARS-CoV-2)

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The antibody neutralizes the wildtype, Alpha B.1.1.7, Beta B.1.351, Gamma P.1, Delta B.1.617.2 and Delta Plus B.1.617.2.1 variant trimeric proteins. Not tested on other variants or on monomeric Spike RBD or S1 protein.

Neutralisation/Blocking

Research Use Only

Monoclonal

LxC1-G10)

Human

IgG1

This human monoclonal antibody recognizes SARS-CoV-2 full-length spike proteins in the native trimeric conformation. This antibody cross-reacts with the wildtype (BPS Bioscience #100728) as well as the Alpha B.1.1.7 (BPS Bioscience #510334), Beta B.1.351 (BPS Bioscience #510333), Beta B.1.351delta242-244 (BPS Bioscience #101091), Gamma P.1 (BPS Bioscience #100989), Delta B.1.617.2 (BPS Bioscience #101147) and Delta Plus B.1.617.2.1 (BPS Bioscience #101165) variant spike trimers [Table of variants]. The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Spike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike Trimer: ACE2 Inhibitor Screening Kits (available for purchase).

-20°C

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