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Spike Trimer Neutralizing Antibody (B.1.617.2, B.1.617.2.1, WT and B.1.1.7 Variants) (Clone hC-A11) (SARS-CoV-2)

Spike Trimer Neutralizing Antibody (B.1.617.2, B.1.617.2.1, WT and B.1.1.7 Variants) (Clone hC-A11) (SARS-CoV-2)

Research Use Only
101061
BPS Bioscience
ApplicationsFunctional Assay, Neutralisation/Blocking
Product group Antibodies
TargetS
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    Spike Trimer Neutralizing Antibody (B.1.617.2, B.1.617.2.1, WT and B.1.1.7 Variants) (Clone hC-A11) (SARS-CoV-2)
  • Delivery Days Customer
    7
  • Antibody Specificity
    The antibody neutralizes the wildtype, B.1.1.7 (Alpha), B.1.617.2 (Delta) and B.1.617.2.1 (Delta Plus) variants of SARS-CoV-2 Spike RBD and Trimeric proteins
  • Applications
    Functional Assay, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    hC-A11
  • Gene ID43740568
  • Target name
    S
  • Target description
    surface glycoprotein
  • Target synonyms
    GU280_gp02; spike glycoprotein; surface glycoprotein
  • Host
    Human
  • Isotype
    IgG1
  • Protein IDP0DTC2
  • Protein Name
    Spike glycoprotein
  • Scientific Description
    This antibody is a humanized monoclonal antibody which recognizes SARS-CoV-2 spike RBD and the full-length spike proteins in the native trimeric conformation. This antibody is derived from rabbit monoclonal C-A11 neutralizing antibody (BPS Bioscience, #101024). It cross-reacts with the wildtype as well as the B.1.617.2 (Delta Variant), B.1.617.2.1 (Delta PLUS Variant), B.1.1.7 (Alpha Variant) RBDs and spike protein trimers [See Table of variants]. The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Sike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike RBD: ACE2 Inhibitor Screening Kits (available for purchase).
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203