Chemical Structure
Chemical Structure
Splitomicin
AG-CR1-0088
Overview
- SupplierAdipoGen Life Sciences
- Product NameSplitomicin
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity>98%
- Molecular FormulaC13H10O2
- Molecular Weight198.2
- Scientific DescriptionChemical. CAS: 5690-03-9. Formula: C13H10O2. MW: 198.2. Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells. - Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p [1-4]. Displays higher activity in vivo than in vitro [1-4]. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket [5]. Shown to have diverse effects also in mammalian cells [6-10].
- SMILESO=C1CCC2=C(O1)C=CC1=CC=CC=C21
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200