Bio-Connect

SQSTM1 / P62 antibody [GT1478]

GTX629890
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
TargetSQSTM1
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Overview

  • Supplier
    GeneTex
  • Product Name
    SQSTM1 / P62 antibody [GT1478]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-Fr: 1:100-1:1000. FACS: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT1478
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID8878
  • Target name
    SQSTM1
  • Target description
    sequestosome 1
  • Target synonyms
    A170, DMRV, EBIAP, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B, sequestosome-1, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, autophagy receptor p62, oxidative stress induced like, phosphotyrosine independent ligand for the Lck SH2 domain p62, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, ubiquitin-binding protein p62
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ13501
  • Protein Name
    Sequestosome-1
  • Scientific Description
    This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Beak JY, Kang HS, Huang W, et al. The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy. J Biol Chem. 2021,297(6):101358. doi: 10.1016/j.jbc.2021.101358
    Read this paper
  • Otsu W, Ishida K, Chinen N, et al. Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells. Sci Rep. 2021,11(1):18555. doi: 10.1038/s41598-021-97956-3
    Read this paper
  • Liang YC, Chang CC, Sheu MT, et al. The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion. Cancers (Basel). 2020,12(6). doi: 10.3390/cancers12061610
    Read this paper
  • Saito Y, Kuse Y, Inoue Y, et al. Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival. Redox Biol. 2018,19:354-363. doi: 10.1016/j.redox.2018.09.004
    Read this paper
  • Gjyshi O, Flaherty S, Veettil MV, et al. Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1. J Virol. 2015,89(4):2268-86. doi: 10.1128/JVI.02742-14
    Read this paper