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ProductsBack/SR-717

SR-717

ORB1089392

CAS Number2375420-34-9

Product group Chemicals

Molecular Weight345.26

Overview

Supplier
Biorbyt
Product Name
SR-717 [2375420-34-9]
Delivery Days Customer
10
CAS Number
2375420-34-9
Certification
Research Use Only
Molecular Formula
C15H9F2N5O3
Molecular Weight
345.26
Scientific Description
SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same closed conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.
SMILES
O=C(O)C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O
UNSPSC
12352200

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