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ProductsBack/sRANKL antibody [12A380]
IHC-P analysis of human tonsil tissue using GTX12125 sRANKL antibody [12A380]. Dilution : 1:50 Antigen retrieval : Heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0)
IHC-P analysis of human tonsil tissue using GTX12125 sRANKL antibody [12A380]. Dilution : 1:50 Antigen retrieval : Heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0)
IHC-P analysis of human tonsil tissue using GTX12125 sRANKL antibody [12A380]. Dilution : 1:50 Antigen retrieval : Heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0)

sRANKL antibody [12A380]

GTX12125
GeneTex
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetTNFSF11
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Overview

  • Supplier
    GeneTex
  • Product Name
    sRANKL antibody [12A380] - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 4 - 6 microg/ml. IHC-P: 1:50 - 1:250. IHC-Fr: 1:10 - 1:500. FACS: 1:10 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    12A380
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID8600
  • Target name
    TNFSF11
  • Target description
    TNF superfamily member 11
  • Target synonyms
    CD254; hRANKL2; ODF; OPGL; OPTB2; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; sOdf; TNF-related activation-induced cytokine; TNLG6B; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDO14788
  • Protein Name
    Tumor necrosis factor ligand superfamily member 11
  • Scientific Description
    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203