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ProductsBack/SRC1 antibody [1135]

SRC1 antibody [1135]

Research Use Only
GTX70250
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
TargetNCOA1
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Overview

  • Supplier
    GeneTex
  • Product Name
    SRC1 antibody [1135]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IP: 0.5 - 2 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1135
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID8648
  • Target name
    NCOA1
  • Target description
    nuclear receptor coactivator 1
  • Target synonyms
    bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; nuclear receptor coactivator 1; renal carcinoma antigen NY-REN-52; RIP160; SRC1; steroid receptor coactivator-1
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ15788
  • Protein Name
    Nuclear receptor coactivator 1
  • Scientific Description
    The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Monkey, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate. Amita M et al., 2010 Jan, Endocrinology
    Read more
  • The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the 3,5-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivators. Jaber BM et al., 2006 Nov, Mol Endocrinol
    Read more
  • Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. Klinge CM et al., 2004 Oct, J Mol Endocrinol
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  • Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Dutertre M et al., 2003 Jul, Mol Endocrinol
    Read more