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SRC1 antibody [1135]

Name: SRC1 antibody [1135]
SKU: GTX70250_G10
Availability: BackOrder

GTX70250

ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation

Product group Antibodies

TargetNCOA1

Overview

Supplier
GeneTex
Product Name
SRC1 antibody [1135]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IP: 0.5 - 2 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
1135
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID8648
Target name
NCOA1
Target description
nuclear receptor coactivator 1
Target synonyms
bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; nuclear receptor coactivator 1; renal carcinoma antigen NY-REN-52; RIP160; SRC1; steroid receptor coactivator-1
Host
Mouse
Isotype
IgG1
Protein IDQ15788
Protein Name
Nuclear receptor coactivator 1
Scientific Description
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate. Amita M et al., 2010 Jan, Endocrinology
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The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the 3,5-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivators. Jaber BM et al., 2006 Nov, Mol Endocrinol
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Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. Klinge CM et al., 2004 Oct, J Mol Endocrinol
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Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Dutertre M et al., 2003 Jul, Mol Endocrinol
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