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The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA869737(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA869737(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA869737(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200)

SRGAP3 Antibody

CSB-PA869737
Cusabio
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetSRGAP3
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Overview

  • Supplier
    Cusabio
  • Product Name
    SRGAP3 Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID9901
  • Target name
    SRGAP3
  • Target description
    SLIT-ROBO Rho GTPase activating protein 3
  • Target synonyms
    ARHGAP14, MEGAP, SRGAP2, WRP, SLIT-ROBO Rho GTPase-activating protein 3, SLIT-ROBO Rho GTPase activating protein 2, WAVE-associated Rac GTPase activating protein, mental disorder-associated GAP, rho GTPase-activating protein 14
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO43295
  • Protein Name
    SLIT-ROBO Rho GTPase-activating protein 3
  • Scientific Description
    SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    41116161

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Figure 1. Western blot analysis of SRGAP3 using anti-SRGAP3 antibody (A06020-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: rat brain tissue lysates, Lane 2: mouse brain tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SRGAP3 antigen affinity purified polyclonal antibody (Catalog # A06020-1) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for SRGAP3 at approximately 140 kDa. The expected band size for SRGAP3 is at 125 kDa.
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