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SRGAP3 Polyclonal Antibody

RD76121A
Reddot Biotech
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetSRGAP3
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    SRGAP3 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.6 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9901
  • Target name
    SRGAP3
  • Target description
    SLIT-ROBO Rho GTPase activating protein 3
  • Target synonyms
    ARHGAP14; MEGAP; mental disorder-associated GAP; rho GTPase-activating protein 14; SLIT-ROBO Rho GTPase activating protein 2; SLIT-ROBO Rho GTPase-activating protein 3; SRGAP2; WAVE-associated Rac GTPase activating protein; WRP
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203