(S,R,S)-AHPC-Me [1948273-02-6]
HY-112078
CAS Number1948273-02-6
Product group Chemicals
Estimated Purity99.96
Molecular Weight444.60
Overview
- SupplierMedChem Express
- Product Name(S,R,S)-AHPC-Me [1948273-02-6]
- Delivery Days Customer10
- CAS Number1948273-02-6
- CertificationResearch Use Only
- Estimated Purity99.96
- Molecular FormulaC23H32N4O3S
- Molecular Weight444.60
- Scientific Description(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 [2].
- SMILESN[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
MSDS
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