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(S,R,S)-AHPC-Me

HY-112078
MedChem Express
CAS Number1948273-02-6
DownloadMSDS
Product group Chemicals
Estimated Purity99.48
Molecular Weight444.601
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (S,R,S)-AHPC-Me [1948273-02-6]
  • Delivery Days Customer
    10
  • CAS Number
    1948273-02-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.48
  • Molecular Formula
    C23H32N4O3S
  • Molecular Weight
    444.601
  • Scientific Description
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein [1] . (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC 50 [2] .
  • SMILES
    N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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