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(S,R,S)-AHPC-Me [1948273-02-6]

(S,R,S)-AHPC-Me [1948273-02-6]

T7752
TargetMol Chemicals
CAS Number1948273-02-6
DownloadMSDS
Product group Chemicals
Estimated Purity99.86%
Molecular Weight444.59
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    (S,R,S)-AHPC-Me [1948273-02-6]
  • Delivery Days Customer
    4
  • CAS Number
    1948273-02-6
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    (S,R,S)-AHPC-Me
  • Estimated Purity
    99.86%
  • Molecular Formula
    C23H32N4O3S
  • Molecular Weight
    444.59
  • Scientific Description
    (S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
  • Shelf life instruction
    3 years
  • SMILES
    C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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Chemical Structure
Product group Chemicals
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