(S,R,S)-AHPC (TFA) [1631137-51-3]

MedChem Express

(S,R,S)-AHPC (TFA) [1631137-51-3]

10

1631137-51-3

Research Use Only

C24H31F3N4O5S

544.59

(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 microM in Ba/F3 cells[1].

FC(F)(F)C(O)=O.O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2

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