(S,R,S)-AHPC TFA [1631137-51-3]
T17927
CAS Number1631137-51-3
Product group Chemicals
Estimated Purity97.99%
Molecular Weight544.59
Overview
- SupplierTargetMol Chemicals
- Product Name(S,R,S)-AHPC TFA [1631137-51-3]
- Delivery Days Customer4
- CAS Number1631137-51-3
- CertificationResearch Use Only
- Chemical Name(S,R,S)-AHPC TFA
- Estimated Purity97.99%
- Molecular FormulaC24H31F3N4O5S
- Molecular Weight544.59
- Scientific Description(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to create PROTACs (e.g., GMB-475), which effectively induce the degradation of BCR-ABL1, demonstrated by an IC50 of 1.11 microM in Ba/F3 cells.
- Shelf life instruction3 years
- SMILESO=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3.O=C(O)C(F)(F)F
- Storage Instruction-20°C
- UNSPSC12352200
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