Immunohistochemistry of paraffin-embedded Human lung using STIL Polyclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human lung using STIL Polyclonal Antibody at dilution of 1:200
STIL Polyclonal Antibody
E-AB-40237
Product group Antibodies
Overview
- SupplierElabscience
- Product NameSTIL Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.
- UNSPSC12352203