STK3 antibody [4G10] - Overexpression Validated

GeneTex

STK3 antibody [4G10] - Overexpression Validated

9

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

4G10

1 mg/ml

Unconjugated

STK3

serine/threonine kinase 3

epididymis secretory sperm binding protein; hippo homolog; KB-1458E12.1; KRS1; mammalian STE20-like protein kinase 2; MST2; MST-2; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; serine/threonine-protein kinase Krs-1; STE20-like kinase MST2

Mouse

IgG2b

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.

Canine, Human, Monkey, Mouse

2°C to 8°C,-20°C or -80°C

12352203