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Syk Inhibitor II dihydrochloride [227449-73-2]

Syk Inhibitor II dihydrochloride [227449-73-2]

T4391
TargetMol Chemicals
CAS Number227449-73-2
Product group Chemicals
Molecular Weight413.22
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Syk Inhibitor II dihydrochloride
  • Delivery Days Customer
    9
  • CAS Number
    227449-73-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Syk Inhibitor II dihydrochloride
  • Molecular Formula
    C14H17Cl2F3N6O
  • Molecular Weight
    413.22
  • Scientific Description
    Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCepsilon, PKCbetaII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 microM, respectively).
  • Shelf life instruction
    3 years
  • SMILES
    Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000

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