![Syk Inhibitor II dihydrochloride [227449-73-2] Syk Inhibitor II dihydrochloride [227449-73-2]](https://www.targetmol.com/group3/M00/02/58/CgoaEGY7MF6ELKY5AAAAALGsNmE299.png)
Syk Inhibitor II dihydrochloride [227449-73-2]
T4391
CAS Number227449-73-2
Product group Chemicals
Molecular Weight413.22
Overview
- SupplierTargetMol Chemicals
- Product NameSyk Inhibitor II dihydrochloride
- Delivery Days Customer9
- CAS Number227449-73-2
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameSyk Inhibitor II dihydrochloride
- Molecular FormulaC14H17Cl2F3N6O
- Molecular Weight413.22
- Scientific DescriptionSpleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCepsilon, PKCbetaII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 microM, respectively).
- Shelf life instruction3 years
- SMILESCl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
- Storage Instruction-20°C
- UNSPSC51202000