Talabostat [149682-77-9]

MedChem Express

Talabostat [149682-77-9]

10

149682-77-9

Research Use Only

C9H19BN2O3

214.07

Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities[1][2][3].

CC(C)[C@H](N)C(N1[C@H](B(O)O)CCC1)=O

12352200