TBC1D7 Antibody, FITC conjugated

Cusabio

TBC1D7 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

TBC1D7

TBC1 domain family member 7

MGCPH, PIG51, TBC7, TBC1 domain family member 7, TBC domain family 7, TS complex subunit 3, Tre2-Bub2-Cdc16 Domain Family Member 7, cell migration-inducing protein 23

Rabbit

IgG

TBC1 domain family member 7

Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.

Human

-20°C or -80°C

41116161