TCL1A blocking peptide

GeneTex

TCL1A blocking peptide

9

Research Use Only

TCL1A

TCL1 family AKT coactivator A

TCL1, T-cell leukemia/lymphoma protein 1A, T cell leukemia/lymphoma 1A, T-cell lymphoma-1, oncogene TCL-1, oncogene TCL1, protein p14 TCL1

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

-20°C or -80°C,2°C to 8°C

41116100

Human