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TD114-2 [436866-52-3]

HY-136679
MedChem Express
CAS Number436866-52-3
Product group Chemicals
Molecular Weight529.58
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Overview

  • Supplier
    MedChem Express
  • Product Name
    TD114-2 [436866-52-3]
  • Delivery Days Customer
    5
  • CAS Number
    436866-52-3
  • Certification
    Research Use Only
  • Molecular Formula
    C30H31N3O6
  • Molecular Weight
    529.58
  • Scientific Description
    TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3beta) (IC50=48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3beta, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3beta. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3beta[1].
  • SMILES
    O=C(N1)C(C2=CN(CCOCCOCCOCCOCC3)C4=CC=CC=C24)=C(C1=O)C5=CN3C6=CC=CC=C56
  • UNSPSC
    12131703

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TD114-2 [436866-52-3]
Product group Chemicals
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Molecular Weight529.58
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