TD114-2 [436866-52-3]
HY-136679
Overview
- SupplierMedChem Express
- Product NameTD114-2 [436866-52-3]
- Delivery Days Customer5
- CAS Number436866-52-3
- CertificationResearch Use Only
- Molecular FormulaC30H31N3O6
- Molecular Weight529.58
- Scientific DescriptionTD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3beta) (IC50=48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3beta, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3beta. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3beta[1].
- SMILESO=C(N1)C(C2=CN(CCOCCOCCOCCOCC3)C4=CC=CC=C24)=C(C1=O)C5=CN3C6=CC=CC=C56
- UNSPSC12131703