TD114-2

Biorbyt

TD114-2 [436866-52-3]

10

436866-52-3

Research Use Only

98.00%

C30H31N3O6

529.58

TD114-2 (compound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3beta) with an IC50 of 48 nM. It forms a hydrogen bond with Arginine 141 (ARG141) in GSK-3beta, an amino acid often found as a negatively charged residue in other kinases, contributing to its high selectivity. TD114-2 is applicable for research on diabetes, neurodegenerative diseases, and other conditions related to GSK-3beta.

O=C1NC(=O)C=2C3=CN(C=4C=CC=CC34)CCOCCOCCOCCOCCN5C=C(C=6C=CC=CC65)C12

-20°C

12352200