TERT antibody [2D8]

GeneTex

TERT antibody [2D8]

9

WB: 1:500 - 1:1000. ICC/IF: 1:50 - 1:200. IHC-P: 1:50 - 1:100. IHC-Fr: 1:50 - 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

2D8

Unconjugated

TERT

telomerase reverse transcriptase

CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; telomerase catalytic subunit; telomerase reverse transcriptase; telomerase-associated protein 2; TP2; TRT

Mouse

IgM

Telomerase reverse transcriptase

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq]

-20°C or -80°C,2°C to 8°C

12352203