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ProductsBack/TET2 Antibody

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA764560ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA764560ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA764560ESR1HU at dilution of 1:100

TET2 Antibody

CSB-PA764560ESR1HU

ApplicationsELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetTET2

Overview

Supplier
Cusabio
Product Name
TET2 Antibody
Delivery Days Customer
20
Applications
ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID54790
Target name
TET2
Target description
tet methylcytosine dioxygenase 2
Target synonyms
IMD75, KIAA1546, MDS, methylcytosine dioxygenase TET2, probable methylcytosine dioxygenase TET2, ten-eleven translocation 2, tet oncogene family member 2
Host
Rabbit
Isotype
IgG
Protein IDQ6N021
Protein Name
Methylcytosine dioxygenase TET2
Scientific Description
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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