TGF beta Receptor III antibody

GeneTex

TGF beta Receptor III antibody

9

WB: 1-2 microg/ml. ELISA: 0.5-1 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

TGFBR3

transforming growth factor beta receptor 3

BGCAN, betaglycan, transforming growth factor beta receptor type 3, TGF-beta receptor type 3, TGF-beta receptor type III, TGFR-3, betaglycan proteoglycan, transforming growth factor beta receptor III

Goat

IgG

Transforming growth factor beta receptor type 3

Most mammalian cells express three abundant high affinity receptors, which can bind and be cross-linked to TGF beta: the type I (53 kDa), type II (65 kDa), and type III (100-280 kDa) receptors, based upon the molecular mass of the cross-linked products analyzed by gel electrophoresis. Tbeta-RI and Tbeta-RII, the type I and II receptors, are type I transmembrane proteins with cytosolic domains containing a serine-threonine kinase. Both receptors are essential for signal transduction. The TGF beta type III receptor, or betaglycan, is a membrane-bound proteoglycan with a short cytoplasmic tail that has no apparent signaling motif. It binds TGF beta 2 (apparent Kd 100 pM) with slightly greater affinity than TGF beta 1 or TGF beta 3 (apparent Kda 300 pM). The main role of betaglycan seems to be in binding and then presenting TGF beta ligand to the signaling receptors Tbeta-RI and Tbeta-RII; overexpression of Tbeta-RIII in L6 myoblasts leads to a dramatic increase in TGF beta 2 binding to Tbeta-RI and Tbeta-RII.

Human

-20°C or -80°C,2°C to 8°C

12352203