Chemical Structure
Thapsigargin (high purity) [67526-95-8]
AG-CN2-0003
Overview
- SupplierAdipoGen Life Sciences
- Product NameThapsigargin (high purity)
- Delivery Days Customer10
- CAS Number67526-95-8
- CertificationResearch Use Only
- Estimated Purity>98%
- Hazard InformationDanger
- Molecular FormulaC34H50O12
- Molecular Weight650.8
- Scientific DescriptionChemical. CAS: 67526-95-8. Formula: C34H50O12. MW: 650.8. Isolated from Thapsia garganica. Intracellular Ca2+ signaling probe. Specific and sensitive inhibitor of SERCA. Non-TPA/PMA tumor promoter. Histamine release inducer. Apoptosis inducer. Mitochondrial dysfunction inducer. NOS modulator. Angiogenesis inhibitor. Stimulator of arachidonic acid metabolism in macrophages. Autophagy inducer. TRAIL sensitizer. - Intracellular Ca2+ signaling probe [1]. Specific and sensitive inhibitor of SERCA [2]. Non-TPA/PMA tumor promoter [3]. Histamine release inducer [4]. Apoptosis inducer [5, 6, 7, 8]. Mitochondrial dysfunction inducer [6, 8]. NOS modulator [9]. Angiogenesis inhibitor [10]. Stimulator of arachidonic acid metabolism in macrophages [11]. Autophagy inducer [12, 13]. TRAIL sensitizer [14]. Inducer of ER-stress in the brain.
- SMILESO=C1O[C@@]2([H])C3=C(C)[C@H](OC(/C(C)=C\C)=O)[C@@H](OC(CCCCCCC)=O)[C@]3([H])[C@@](C)(OC(C)=O)C[C@H](OC(CCC)=O)[C@]2(O)[C@@]1(O)C
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases: M. Treiman, et al.; Trends Pharmacol. Sci. 19,131 (1998)
- Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations: Y. Sagara, & G. Inesi; J. Biol. Chem. 266, 13503 (1991)
- Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis: H. Hakii, et al. J. Cancer. Res. Clin. Oncol. 111, 177 (1986)
- On the mechanism of histamine release induced by thapsigargin from Thapsia garganica L: S.A. Patkar, et al.; Agents Actions 9, 53 (1979)
- Thapsigargin, a Ca(2+)-ATPase inhibitor, depletes the intracellular Ca2+ pool and induces apoptosis in human hepatoma cells: A. Tsukamoto & Y. Kaneko; Cell Biol. Int. 17, 969 (1993)
- Thapsigargin induces mitochondrial dysfunction and apoptosis in the mastocytoma P815 cell line and in mouse thymocytes: J.P. Beaver & P. Waring; Cell Death Differ. 3, 415 (1996)
- Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells: B. Tombal, et al.; Prostate 43, 303 (2000)
- Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis: J.R. Hom, et al.; J. Cell Physiol. 212, 498 (2007)
- Thapsigargin, a Ca(2+)-ATPase inhibitor, relaxes rat aorta via nitric oxide formation: H. Moritoki, et al.; Life Sci. 54, PL153 (1994)
- Thapsigargin inhibits angiogenesis in the rat isolated aorta: studies on the role of intracellular calcium pools: N. Shukla, et al.; Cardiovasc. Res. 49, 681 (2001)