THZ-P1-2

MedChem Express

THZ-P1-2 [2058075-45-7]

9

2058075-45-7

Research Use Only

99.86

C31H29N7O2

531.61

THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC 50 of 190 nM for PI5P4Kalpha. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kalpha/beta/gamma. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines [1] .

O=C(C(C=C1)=CC=C1NC(/C=C/CN(C)C)=O)NC2=CC=CC(NC3=CC(C4=CNC5=CC=CC=C45)=NC=N3)=C2

2°C to 8°C

12352200