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THZ-P1-2 [2058075-45-7]

THZ-P1-2 [2058075-45-7]

T39459
TargetMol Chemicals
CAS Number2058075-45-7
Product group Chemicals
Molecular Weight531.61
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    THZ-P1-2 [2058075-45-7]
  • Delivery Days Customer
    14
  • CAS Number
    2058075-45-7
  • Certification
    Research Use Only
  • Chemical Name
    THZ-P1-2
  • Molecular Formula
    C31H29N7O2
  • Molecular Weight
    531.61
  • Scientific Description
    THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.THZ-P1-2 induces cell death and mitochondrial damage, and can be used in the study of leukemias.
  • Shelf life instruction
    3 years
  • SMILES
    CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Sivakumaren SC, Shim H, Zhang T, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020,27(5):525-537.e6. doi: 10.1016/j.chembiol.2020.02.003
    Read this paper