TIF1 gamma antibody [9D4]

GeneTex

TIF1 gamma antibody [9D4]

9

WB: 1:500. ICC/IF: 1:100. IHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

9D4

1 mg/ml

Unconjugated

TRIM33

tripartite motif containing 33

DDH4, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, E3 ubiquitin-protein ligase TRIM33, RET-fused gene 7 protein, RING-type E3 ubiquitin transferase TRIM33, TIF1-gamma, ectodermin homolog, protein Rfg7, transcriptional intermediary factor 1 gamma

Mouse

IgG2a

E3 ubiquitin-protein ligase TRIM33

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

-20°C or -80°C,2°C to 8°C

12352203