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Timeless antibody

Name: Timeless antibody
SKU: GTX129604_G10
Availability: BackOrder

GTX129604

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman, Mouse

TargetTIMELESS

Overview

Supplier
GeneTex
Product Name
Timeless antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:2000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID8914
Target name
TIMELESS
Target description
timeless circadian regulator
Target synonyms
hTIM; protein timeless homolog; TIM; TIM1; timeless circadian clock 1; timeless homolog; Tof1 homolog
Host
Rabbit
Isotype
IgG
Protein IDQ9UNS1
Protein Name
Protein timeless homolog
Scientific Description
Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Truong LN et al., 2013 May 7, Proc Natl Acad Sci U S A
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