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TIMP1 antibody [C2C3], C-term

GTX108254
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetTIMP1
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Overview

  • Supplier
    GeneTex
  • Product Name
    TIMP1 antibody [C2C3], C-term
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7076
  • Target name
    TIMP1
  • Target description
    TIMP metallopeptidase inhibitor 1
  • Target synonyms
    CLGI, EPA, EPO, HCI, TIMP, TIMP-1, metalloproteinase inhibitor 1, collagenase inhibitor, epididymis secretory sperm binding protein, erythroid potentiating activity, fibroblast collagenase inhibitor, tissue inhibitor of metalloproteinases 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP01033
  • Protein Name
    Metalloproteinase inhibitor 1
  • Scientific Description
    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Perpétuo L, Barros AS, Dalsuco J, et al. Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study. Int J Mol Sci. 2022,23(21). doi: 10.3390/ijms232113579
    Read this paper
  • Chang HH, Chen IL, Wang YL, et al. Regulation of the regenerative activity of dental pulp stem cells from exfoliated deciduous teeth (SHED) of children by TGF-β1 is associated with ALK5/Smad2, TAK1, p38 and MEK/ERK signaling. Aging (Albany NY). 2020,12(21):21253-21272. doi: 10.18632/aging.103848
    Read this paper
  • Chen S, Liao B, Jin X, et al. M(3) receptor modulates extracellular matrix synthesis via ERK1/2 signaling pathway in human bladder smooth muscle cells. J Cell Biochem. 2020,121(11):4496-4504. doi: 10.1002/jcb.29688
    Read this paper
  • Laudanski P, Charkiewicz R, Kuzmicki M, et al. Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014,172:85-92. doi: 10.1016/j.ejogrb.2013.10.007
    Read this paper
  • Lin YC, Tsai PH, Lin CY, et al. Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells. PLoS One. 2013,8(8):e71903. doi: 10.1371/journal.pone.0071903
    Read this paper