ProductsBack/TIMP2 antibody [3A4]

IHC-P analysis of human colon carcinoma tissue using GTX21828 TIMP2 antibody [3A4].

TIMP2 antibody [3A4]

Name: TIMP2 antibody [3A4]
SKU: GTX21828_G10
Availability: BackOrder

GTX21828

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetTIMP2

Overview

Supplier
GeneTex
Product Name
TIMP2 antibody [3A4]
Delivery Days Customer
9
Application Supplier Note
IHC-P: 1:25-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
3A4
Conjugate
Unconjugated
Gene ID7077
Target name
TIMP2
Target description
TIMP metallopeptidase inhibitor 2
Target synonyms
CSC-21K; DDC8; metalloproteinase inhibitor 2; testicular secretory protein Li 57; tissue inhibitor of metalloproteinases 2
Host
Mouse
Isotype
IgG2a
Protein IDP16035
Protein Name
Metalloproteinase inhibitor 2
Scientific Description
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Storage Instruction
2°C to 8°C
UNSPSC
12352203

p85alpha Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation. Wang J et al., 2019 Sep, Neoplasia
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Simulated physiological stretch-induced proliferation of human bladder smooth muscle cells is regulated by MMPs. Bu S et al., 2014 Dec 15, Arch Biochem Biophys
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Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells. Lin YC et al., 2013, PLoS One
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Differential structural remodeling of the left-atrial posterior wall in patients affected by mitral regurgitation with or without persistent atrial fibrillation: a morphological and molecular study. Corradi D et al., 2012 Mar, J Cardiovasc Electrophysiol
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