TIMP2 antibody

GeneTex

TIMP2 antibody

9

Reacts with reduced TIMP-2

WB: 1:1,000~1:5000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TIMP2

TIMP metallopeptidase inhibitor 2

CSC-21K; DDC8; metalloproteinase inhibitor 2; testicular secretory protein Li 57; tissue inhibitor of metalloproteinases 2

Rabbit

IgG

Metalloproteinase inhibitor 2

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis.The activation and activity of MMPs are regulated by a family of endogenous inhibitors, tissue inhibitors of metalloproteinase (TIMP). TIMP2 (also called CSC-21K) is a 21 kDa glycoprotein that is expressed by a variety of cell types. It forms a non-covalent, stoichiometric complex with both latent and active MMPs. TIMP2 shows a preference for MMP-2. TIMPs are capable of altering the metastatic potential of cancer cells and have been shown to inhibit invasion and metastasis in animal models.

Human

-20°C or -80°C,2°C to 8°C

12352203