Tirabrutinib [1351636-18-4]

TargetMol Chemicals

Tirabrutinib [1351636-18-4]

4

1351636-18-4

Chemical

Research Use Only

Tirabrutinib

99.75%

C25H22N6O3

454.48

Tirabrutinib (GS-4059) (ONO-4059) is an orally active Brutons Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of autoimmune diseases and hematological malignancies.

3 years

CC#CC(=O)N1CC[C@H](C1)n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O

-20°C

12352200