TL12-186

MedChem Express

TL12-186 [2250025-88-6]

10

2250025-88-6

Research Use Only

99.63

C44H51ClN10O9S

931.46

TL12-186 is a Cereblon -dependent multi-kinase PROTAC degrader. Multi-kinases include CDK , BTK , FLT3 , Aurora kinases , TEC , ULK , ITK , et al. TL12-186 inhibits CDK2/cyclin A ( IC 50 =73 nM) and CDK9/cyclin T1 ( IC 50 =55 nM) [1] .

O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C=C2)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O

2°C to 8°C

12352200