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ProductsBack/TLR4 antibody [HTA125]

TLR4 antibody [HTA125]

GTX75737
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking
DownloadDatasheet
Product group Antibodies
ReactivityCanine, Feline, Guinea Pig, Human, Porcine, Primate
TargetTLR4
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Overview

  • Supplier
    GeneTex
  • Product Name
    TLR4 antibody [HTA125]
  • Delivery Days Customer
    9
  • Application Supplier Note
    FACS: 1/10-1/25. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    HTA125
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7099
  • Target name
    TLR4
  • Target description
    toll like receptor 4
  • Target synonyms
    ARMD10; CD284; homolog of Drosophila toll; hToll; TLR-4; TOLL; toll like receptor 4 protein; toll-like receptor 4
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDO00206
  • Protein Name
    Toll-like receptor 4
  • Scientific Description
    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
  • Reactivity
    Canine, Feline, Guinea Pig, Human, Porcine, Primate
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • A Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo. Zhang X et al., 2022, Front Pharmacol
    Read more
  • Morphologically, immunohistochemically and PCR proven lymphocytic viral peri-, endo-, myocarditis in patients with fatal COVID-19. Kogan E et al., 2022 Feb 17, Diagn Pathol
    Read more
  • Suppression of Inflammatory and Fibrotic Signals by Cinnamon (Cinnamomum cassia) and Cinnamaldehyde in Cyclophosphamide-Induced Overactive Bladder in Mice. Chen LL et al., 2021, Evid Based Complement Alternat Med
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  • Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK-AMPK-Sirt1-Associated Signaling Pathway in Mouse Models. Chien LH et al., 2021 Oct 15, Antioxidants (Basel)
    Read more
  • Fiber scaffold bioartificial liver therapy relieves acute liver failure and extrahepatic organ injury in pigs. Weng J et al., 2021, Theranostics
    Read more
  • Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Huang CY et al., 2020 Jun 10, Nutrients
    Read more
  • PE_PGRS31-S100A9 Interaction Promotes Mycobacterial Survival in Macrophages Through the Regulation of NF-kappaB-TNF-alpha Signaling and Arachidonic Acid Metabolism. Liu S et al., 2020, Front Microbiol
    Read more
  • 6-Bromoindirubin-3-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-kappaB and TLR4/MAPK Signaling Pathways. Liu C et al., 2019 Dec, Inflammation
    Read more
  • Cryptotanshinone inhibits prostaglandin E2 production and COX-2 expression via suppression of TLR4/NF-kappaB signaling pathway in LPS-stimulated Caco-2 cells. Cao SG et al., 2018 Mar, Microb Pathog
    Read more
  • 3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways. Chao W et al., 2017 Sep, Int Immunopharmacol
    Read more