Western blot analysis of extracts of THP-1 cells using TNFR2 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of THP-1 cells using TNFR2 Polyclonal Antibody at dilution of 1:1000.
TNFRSF1B Polyclonal Antibody
E-AB-60182
Product group Antibodies
Overview
- SupplierElabscience
- Product NameTNFRSF1B Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
- UNSPSC12352203