Tolebrutinib

MedChem Express

Tolebrutinib [1971920-73-6]

5

1971920-73-6

Research Use Only

99.79

C26H25N5O3

455.51

Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK) , with IC 50 s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS) [1] [2] .

O=C(N1[C@H]2CN(C(C=C)=O)CCC2)N(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C1C=CN=C5N

-20°C,2°C to 8°C

12352200