ICC/IF analysis of HeLa cells using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361]. Green : Primary antibody Red : nucleus
![IHC-P analysis of human tonsil tissue using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].](https://www.genetex.com/upload/website/prouct_img/normal/GTX35137/GTX35137_20200115_IHC-P_1412_w_23060801_377.webp "IHC-P analysis of human tonsil tissue using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].")
![IHC-P analysis of human bladder carcinoma tissue using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].](https://www.genetex.com/upload/website/prouct_img/normal/GTX35137/GTX35137_20200115_IHC-P_315_w_23060801_487.webp "IHC-P analysis of human bladder carcinoma tissue using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].")
![WB analysis of HeLa cell lysate using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].](https://www.genetex.com/upload/website/prouct_img/normal/GTX35137/GTX35137_20200115_WB_167_w_23060801_628.webp "WB analysis of HeLa cell lysate using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].")
![WB analysis of HepG2, HeLa, and 3T3 cell lysates using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].](https://www.genetex.com/upload/website/prouct_img/normal/GTX35137/GTX35137_20200115_WB_247_w_23060801_525.webp "WB analysis of HepG2, HeLa, and 3T3 cell lysates using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361].")
ICC/IF analysis of HeLa cells using GTX35137 Topoisomerase II alpha antibody [TOP2A/1361]. Green : Primary antibody Red : nucleus
Topoisomerase II alpha antibody [TOP2A/1361]
GTX35137
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse
TargetTOP2A
Overview
- SupplierGeneTex
- Product NameTopoisomerase II alpha antibody [TOP2A/1361]
- Delivery Days Customer9
- Application Supplier NoteWB: 1-2microg/ml. ICC/IF: 1-2microg/ml. IHC-P: 1-2microg/ml for 30 min at RT. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDTOP2A/1361
- Concentration0.2 mg/ml
- ConjugateUnconjugated
- Gene ID7153
- Target nameTOP2A
- Target descriptionDNA topoisomerase II alpha
- Target synonymsDNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase 2-alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; TOP2; TOP2alpha; TOPIIA; topoisomerase (DNA) II alpha 170kDa; TP2A
- HostMouse
- IsotypeIgG2b
- Protein IDP11388
- Protein NameDNA topoisomerase 2-alpha
- Scientific DescriptionThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203