TP0427736 (hydrochloride)

MedChem Express

TP0427736 (hydrochloride) [2459963-17-6]

10

2459963-17-6

Research Use Only

99.22

C14H11ClN4S2

334.85

TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC 50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC 50 =836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-beta1 with an IC 50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) [1] .

CC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)N=CN2)=N1.[H]Cl

-20°C,2°C to 8°C

12352200