TPMT antibody [AT2E7]

GeneTex

TPMT antibody [AT2E7]

9

WB: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

AT2E7

1 mg/ml

Unconjugated

TPMT

thiopurine S-methyltransferase

TPMTD, thiopurine S-methyltransferase, S-adenosyl-L-methionine:thiopurine S-methyltransferase

Mouse

IgG1

Thiopurine S-methyltransferase

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

-20°C or -80°C,2°C to 8°C

12352203