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TPMT Polyclonal Antibody

RD218800A
Reddot Biotech
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetTPMT
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    TPMT Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.96 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7172
  • Target name
    TPMT
  • Target description
    thiopurine S-methyltransferase
  • Target synonyms
    S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine S-methyltransferase; TPMTD
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203