Trametinib

MedChem Express

Trametinib [871700-17-3]

10

871700-17-3

Research Use Only

99.96

C26H23FIN5O4

615.39

Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

CC(NC1=CC=CC(N(C2=O)C(C(C(N2C3CC3)=O)=C(N4C)NC5=CC=C(C=C5F)I)=C(C4=O)C)=C1)=O

-20°C,2°C to 8°C

12352200