TRAP80 antibody [C1C3]
GTX115241
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetMED17
Overview
- SupplierGeneTex
- Product NameTRAP80 antibody [C1C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9440
- Target nameMED17
- Target descriptionmediator complex subunit 17
- Target synonymsCRSP6, CRSP77, DRIP80, SRB4, TRAP80, mediator of RNA polymerase II transcription subunit 17, ARC77, CRSP complex subunit 6, activator-recruited cofactor 77 kDa component, cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa, epididymis secretory sperm binding protein, thyroid hormone receptor-associated protein complex 80 kDa component, transcriptional coactivator CRSP77, vitamin D3 receptor-interacting protein complex 80 kDa component
- HostRabbit
- IsotypeIgG
- Protein IDQ9NVC6
- Protein NameMediator of RNA polymerase II transcription subunit 17
- Scientific DescriptionThe activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Dimitrova E, Feldmann A, van der Weide RH, et al. Distinct roles for CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction. Nat Struct Mol Biol. 2022,29(10):1000-1010. doi: 10.1038/s41594-022-00840-5Read this paper
- Kawachi T, Masuda A, Yamashita Y, et al. Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors. EMBO J. 2021,40(22):e107485. doi: 10.15252/embj.2020107485Read this paper






