Troponin I skeletal muscle antibody [12F10]

GeneTex

Troponin I skeletal muscle antibody [12F10]

9

Cross-reaction with cardiac TnI is less than 0.05%.

Western Blot, Purification/Extraction/Isolation

Research Use Only

Monoclonal

12F10

Unconjugated

TNNI2

troponin I2, fast skeletal type

AMCD2B; DA2B; DA2B1; FSSV; fsTnI; troponin I fast twitch 2; troponin I type 2 (skeletal, fast); troponin I, fast skeletal muscle; troponin I, skeletal, fast

Mouse

IgG2b

Troponin I, fast skeletal muscle

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Human

2°C to 8°C

12352203