TSG101 antibody [4A10] - KO/KD, Orthogonal Validated
GTX70255
ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Hamster, Human, Monkey, Mouse, Porcine, Rat, Zebra Fish
TargetTSG101
Overview
- SupplierGeneTex
- Product NameTSG101 antibody [4A10] - KO/KD, Orthogonal Validated
- Delivery Days Customer9
- Antibody SpecificityKnockdown/Knockout validation was supported by references (PMID:27226592)
- ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID4A10
- Concentration1.8 mg/ml
- ConjugateUnconjugated
- Gene ID7251
- Target nameTSG101
- Target descriptiontumor susceptibility 101
- Target synonymsESCRT-I complex subunit TSG101; TSG10; tumor susceptibility gene 10; tumor susceptibility gene 101; tumor susceptibility gene 101 protein; tumor susceptibility protein; VPS23
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
- ReactivityCanine, Hamster, Human, Monkey, Mouse, Porcine, Rat, Zebra Fish
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Zebrafish Melanoma-Derived Interstitial EVs Are Carriers of ncRNAs That Induce Inflammation. Biagini V et al., 2022 May 14, Int J Mol SciRead more
- LAMP2A regulates the loading of proteins into exosomes. Ferreira JV et al., 2022 Mar 25, Sci AdvRead more
- The Chaperone Protein GRP78 Promotes Survival and Migration of Head and Neck Cancer After Direct Radiation Exposure and Extracellular Vesicle-Transfer. Schneider M et al., 2022, Front OncolRead more
- Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes. Leary N et al., 2022 Feb, J Extracell VesiclesRead more
- Tumor Susceptibility Gene 101 (TSG101) Contributes to Virion Formation of Porcine Reproductive and Respiratory Syndrome Virus via Interaction with the Nucleocapsid (N) Protein along with the Early Secretory Pathway. Zhang L et al., 2022 Mar 23, J VirolRead more
- HIV-1 Nef Protein Affects Cytokine and Extracellular Vesicles Production in the GEN2.2 Plasmacytoid Dendritic Cell Line. Aiello A et al., 2021 Dec 31, VirusesRead more
- PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Gulluni F et al., 2021 Dec 10, ScienceRead more
- Human Olfactory Ensheathing Cell-derived Extracellular Cesicles: miRNA Profile and Neuroprotective Effect. Tu YK et al., 2021, Curr Neurovasc ResRead more
- Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles. Volz AK et al., 2021 Sep 27, Nat CommunRead more
- LncRNA RP11-465B22.8 triggers esophageal cancer progression by targeting miR-765/KLK4 axis. Hu R et al., 2021 Sep 24, Cell Death DiscovRead more