TTC-352

Biorbyt

TTC-352

10

1607819-68-0

Research Use Only

C20H13FO3S

352.3788278

TTC352 is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.TTC 352 yields an H-bond with Glu353, allows Asp351-to-helix 12 (H12) interaction, sealing ERalphas ligand-binding domain, recruiting E2-enriched coactivators, and triggering rapid ERalpha-induced unfolded protein response (UPR) and apoptosis.TTC-352 is a less potent full estrogen agonist compared to E2, allowing H12 to seal the LBD, which recruits many E2-enriched coactivators, and induces rapid ERalpha-mediated UPR and apoptosis.

S1C(=C(C2C=CC(=CC=2)F)C2C=CC(=CC1=2)O)OC1C=CC(=CC=1)O

12352200