TTC-352 [1607819-68-0]

TargetMol Chemicals

TTC-352 [1607819-68-0]

72

1607819-68-0

Research Use Only

TTC-352

C20H13FO3S

352.38

TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring 17beta-estradiol (E2) and targets and binds to ERa located in the nucleus. This causes translocation of ERa to extranuclear sites. Nuclear export of ERa prevents normal ER-mediated signaling and inhibits proliferation of ER-positive tumor cells.

3 years

O(C1=C(C=2C(S1)=CC(O)=CC2)C3=CC=C(F)C=C3)C4=CC=C(O)C=C4

-20°C

12352200