Tuberin Rabbit mAb

Biorbyt

Tuberin Rabbit mAb

10

Flow Cytometry, Western Blot, ImmunoHistoChemistry

WB 1:500~1:2000 IHC 1:50~1:200 FC 1:50 FC, IHC, WB

Research Use Only

Monoclonal

Unconjugated

TSC2

TSC complex subunit 2

LAM, PPP1R160, TSC4, tuberin, protein phosphatase 1, regulatory subunit 160, tuberous sclerosis 2 protein

Rabbit

IgG

Tuberin

Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity.

Human, Mouse, Rat

-20°C,2°C to 8°C

12352203