Bio-Connect

TXNDC5 antibody

GTX106914
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetTXNDC5
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Overview

  • Supplier
    GeneTex
  • Product Name
    TXNDC5 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID81567
  • Target name
    TXNDC5
  • Target description
    thioredoxin domain containing 5
  • Target synonyms
    ENDOPDI; endoplasmic reticulum protein ERp46; endoplasmic reticulum resident protein 46; endothelial protein disulphide isomerase; epididymis secretory sperm binding protein; ER protein 46; ERP46; HCC2; HCC-2; PDIA15; protein disulfide isomerase family A, member 15; STRF8; thioredoxin domain containing 5 (endoplasmic reticulum); thioredoxin domain-containing protein 5; thioredoxin related protein; thioredoxin-like protein p46; UNQ364
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ8NBS9
  • Protein Name
    Thioredoxin domain-containing protein 5
  • Scientific Description
    This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors.
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  • Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma. Hedrick E et al., 2019 Nov, Mol Cancer Res
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  • Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. Hedrick E et al., 2015 Oct, Endocr Relat Cancer
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  • The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Lee SO et al., 2014 Apr, Mol Cancer Res
    Read more