UBE2V1 Antibody

Cusabio

UBE2V1 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

UBE2V1

ubiquitin conjugating enzyme E2 V1

CIR1; CROC1; CROC-1; DNA-binding protein; TRAF6-regulated IKK activator 1 beta Uev1A; UBE2V; ubiquitin-conjugating enzyme E2 variant 1; UEV1; UEV-1; UEV1A

Rabbit

IgG

Ubiquitin-conjugating enzyme E2 variant 1

Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \Lys-63\-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

Human

-20°C or -80°C

12352203